Our immune system wields immense power, but things don’t always go to plan. Sometimes it tries to help and succeeds. Other times, it fails and makes things worse. Gamma delta T-Cells are extremely effective at detecting and killing cancer cells. But certain subsets release IL-17, and depending on the type of cancer, that can make things worse.

The urea cycle detoxifies ammonia by converting it to urea, with arginase-1 catalyzing the final step: hydrolysis of arginine to urea and ornithine. Argininemia (arginase-1 deficiency) is a rare autosomal recessive disorder caused by pathogenic variants in ARG1 that markedly reduce enzyme activity. Loss of arginase function limits nitrogen excretion, leading to progressive hyperargininemia, accumulation of neurotoxic guanidino compounds, and variable hyperammonemia. Unlike pr

Introduction Pulmonary Arterial Hypertension (PAH) is a progressive, life-threatening disorder characterized by high blood pressure in the arteries of the lungs. For years, standard treatments acted primarily as vasodilators—opening up blood vessels to improve flow. However, these therapies often managed symptoms without addressing the underlying structural changes in the pulmonary vessels. Sotatercept (marketed as Winrevair) represents a fundamental shift in this therapeutic