Parth Rastogi

Introduction In a healthy person, the pancreas performs a quiet, remarkable balancing act every minute of every day. It senses the amount of sugar in the blood and releases just enough insulin to keep those levels in a safe, narrow range — never too high, never too low. For the hundreds of millions of people living with diabetes, that automatic system has broken down. According to the International Diabetes Federation, roughly 589 million adults worldwide now live with diabetes, a number...

Tegoprubart and Islet Cell Transplantation The recent clinical progress of tegoprubart, a targeted monoclonal antibody developed by Eledon Pharmaceuticals, represents a significant paradigm shift in this field. By selectively blocking the CD40 ligand (CD40L) pathway, tegoprubart provides a mechanism to protect transplanted islet cells without the nephrotoxicity and neurotoxicity associated with traditional calcineurin inhibitors, such as tacrolimus. For individuals with type 1 diabetes (T1D),...

Figure 1: Diabetes Managment Introduction: The Growing Crisis Diabetes is one of the most common chronic diseases on the planet. Diabetes mellitus has reached the level of a global health emergency. As of 2024–2025, approximately 589 million adults worldwide are living with the condition, and this number continues to rise. For decades, managing diabetes has meant a demanding daily routine pricking fingers to check blood sugar, calculating insulin doses, counting carbohydrates, and living with...