Janice Chan

Introduction Precision medicine is often associated with cancer care. Advances in tumor sequencing, targeted therapies, and biomarker-guided clinical trials have positioned oncology as the flagship application of this approach, shaping public perception to equate precision medicine exclusively with cancer treatment. However, what if these advancements extend beyond oncology? At its core, precision medicine is about understanding variability in genetics, environment, and lifestyle to improve...

Why the Same Chemotherapy Can Help One Patient and Harm Another? Introduction Chemotherapy remains a cornerstone of cancer treatment across many malignancies, yet patient responses vary dramatically. Two individuals receiving the same regimen can experience entirely different outcomes, ranging from excellent tumour control to severe, life-threatening toxicity. For decades, these differences were largely attributed to age, organ function, or chance. Pharmacogenomics has revealed a far more...

Introduction Imagine a cancer treatment designed entirely for you, built using the exact mutations inside your tumor, and created with the goal of training your immune system to eliminate every trace of cancer cells that remain after surgery or therapy. This idea once sounded like science fiction. Today, it’s becoming reality.Ultra-personalized cancer vaccines are emerging as one of the most exciting developments in precision medicine, offering a new way to harness our immune system with...